Bis(2-Methoxyethyl)amine → HCID 69335496, compound

HRID 1292705Notes

Reaction equation

HRID 1292705 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([O:11][CH3:12])[N:3]=1.[CH3:13][O:14][CH2:15][CH2:16][NH:17][CH2:18][CH2:19][O:20][CH3:21]>C(O)C>[CH3:13][O:14][CH2:15][CH2:16][N:17]([CH2:18][CH2:19][O:20][CH3:21])[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([O:11][CH3:12])[N:3]=1

Participants

4

Reactant 2

HCID 2383Bis(2-Methoxyethyl)amineHCID 27950292-Chloro-6-methoxy-3-nitropyridine

Product 1

HCID 69335496HCID 69335496, compoundYield 90.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4 g (0.0212 mol) of the product 2-chloro-3-nitro-6-methoxypyridine, 50 ml of ethanol and 6.32 ml (0.0424 mol) of bis(2-methoxyethyl)amine are placed in a fully equipped round-bottomed flask. The mixture is refluxed for 2 hours with stirring and is then poured onto an ice/water mixture with stirring. The precipitate formed is filtered off by suction and dried under vacuum to constant weight. 5.47 g of yellow powder are obtained, ie a yield of 90.6%.

Workup

  1. temperatureThe mixture is refluxed for 2 hours
  2. stirringwith stirring
  3. customThe precipitate formed
  4. filtrationis filtered off by suction
  5. customdried under vacuum to constant weight

Sources & evidence

ORD record
ord-99b7da3f0cc541afa3e5dc55ff387482
Source dataset
uspto-grants-2007_07
Patent number
US07238211B2

Reaction notes

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