反应详情

To a suspension of the product of step (b) (20 g) in toluene (250 ml) and tetrabutylammonium chloride (0.3 g) was added thionyl chloride (40 ml) and the mixture refluxed for 4 hrs. A further aliquot of thionyl chloride-(40 ml) was added and the mixture was refluxed for a further 4 hrs. Solvents were evaporated and the residue was azeotroped with toluene to give the sub-title compound as a solid (20 g). This was used without further purification.

1. temperaturethe mixture refluxed for 4 hrs
2. temperaturethe mixture was refluxed for a further 4 hrs
3. customSolvents were evaporated
4. customthe residue was azeotroped with toluene