Sodium ethoxide → 5-Bromo-4-ethoxy-6-trifluoromethylpyrimidine

0.94 g (13.77 mmoles) of sodium ethoxide was added, at room temperature, to a solution of 3.00 g (11.48 mmoles) of 5-bromo-4-chloro-6-trifluoromethylpyrimidine dissolved in 50 ml of ethanol. The mixture was stirred to give rise to a reaction. After confirmation of the completion of the reaction, the reaction mixture was subjected to vacuum distillation to remove the solvent contained therein. The residue was poured into water, followed by extraction with chloroform. The resulting organic layer was washed with water and an aqueous sodium chloride solution in this order and then dried over anhydrous magnesium sulfate. The resulting solution was subjected to vacuum distillation to remove the solvent contained therein. The residue was purified by silica gel column chromatography to obtain 2.44 g (yield: 82.9%) of 5-bromo-4-ethoxy-6-trifluoromethylpyrimidine.

1. customto give rise
2. customto a reaction
3. customAfter confirmation of the completion of the reaction
4. distillationthe reaction mixture was subjected to vacuum distillation
5. customto remove the solvent
6. additionThe residue was poured into water
7. extractionfollowed by extraction with chloroform
8. washThe resulting organic layer was washed with water
9. dry with materialan aqueous sodium chloride solution in this order and then dried over anhydrous magnesium sulfate
10. distillationThe resulting solution was subjected to vacuum distillation
11. customto remove the solvent
12. customThe residue was purified by silica gel column chromatography

ORD record

ord-829ec265b3b64f82b85d06e2dbb8bb8d

Source dataset

uspto-grants-2007_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07238689B2