HCID 58905142, compound → HCID 58905135, compound

HRID 1292859Notes

Reaction equation

HRID 1292859 reaction equation
[F:1][C:2]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:3]=1[O:4][C:5]1[CH:6]=[CH:7][C:8]([N+:14]([O-])=O)=[C:9]([CH:13]=1)[C:10]([NH2:12])=[O:11]>CCO.[Pd]>[NH2:14][C:8]1[CH:7]=[CH:6][C:5]([O:4][C:3]2[CH:17]=[CH:18][C:19]([F:21])=[CH:20][C:2]=2[F:1])=[CH:13][C:9]=1[C:10]([NH2:12])=[O:11]

Participants

4

Reactant 1

HCID 58905142HCID 58905142, compound

Product 1

HCID 58905135HCID 58905135, compoundYield 96.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To compound (1C) (27 g, 0.09 mol) in EtOH was added palladium on activated carbon (2.7 g), and the mixture was stirred under hydrogen for 18 h. The suspension was filtered through celite and the filtrate concentrated and dried in vacuo to yield 23 g of 2-amino-5-(2,4-difluoro-phenoxy)-benzamide (1D).

Workup

  1. filtrationThe suspension was filtered through celite
  2. concentrationthe filtrate concentrated
  3. customdried in vacuo

Sources & evidence

ORD record
ord-c7ee8ee6522443669ec5473ec4ef5dfb
Source dataset
uspto-grants-2007_07
Patent number
US07238698B2

Reaction notes

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