4-Methyl-2-oxo-4-phenylpentanoic acid ethyl ester → 2,4-Diphenyl-2-hydroxy-4-methylpentanoic Acid-ethyl Ester

HRID 1292978Notes

Reaction equation

HRID 1292978 reaction equation
[CH2:1]([O:3][C:4](=[O:17])[C:5](=[O:16])[CH2:6][C:7]([CH3:15])([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:8])[CH3:2].[C:18]1([Mg]Cl)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.C1COCC1>>[CH2:1]([O:3][C:4](=[O:17])[C:5]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([OH:16])[CH2:6][C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)([CH3:8])[CH3:15])[CH3:2]

Participants

3

Reactant 2

HCID 113337794-Methyl-2-oxo-4-phenylpentanoic acid ethyl esterHCID 178420681HCID 178420681, compound

Product 1

HCID 694235842,4-Diphenyl-2-hydroxy-4-methylpentanoic Acid-ethyl Ester

Procedure

Analogously to Example 1, 1.0 g of 4-methyl-4-phenyl-2-oxopentanoic acid-ethyl ester is converted with 2.14 ml of a 2 M phenylmagnesium chloride-THF solution into 980 mg of product.

Sources & evidence

ORD record
ord-4a17ea35d5444480836501f0eb3de796
Source dataset
uspto-grants-2007_07
Patent number
US07238707B2

Reaction notes

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