Hydrochloric Acid → HCID 178483207, compound

HRID 1293036Notes

Reaction equation

HRID 1293036 reaction equation
Cl.[C:2]1([CH:8]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[CH2:9][NH:10][C:11]2[N:19]=[C:18]([CH2:20][NH:21][C:22](=[O:33])[N:23]([CH3:32])[CH2:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=3)[N:17]=[C:16]3[C:12]=2[N:13]=[CH:14][N:15]3C2CCCCO2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO>[C:40]1([CH:8]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:9][NH:10][C:11]2[N:19]=[C:18]([CH2:20][NH:21][C:22](=[O:33])[N:23]([CH3:32])[CH2:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=3)[N:17]=[C:16]3[C:12]=2[N:13]=[CH:14][NH:15]3)[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20816804HCID 20816804, compound

Product 1

HCID 178483207HCID 178483207, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Aqueous hydrochloric acid (2M, 5 ml) was added to a solution of N′-({6-[(2,2-diphenylethyl)amino]-9-tetrahydro-2H-pyran-2-yl-9H-purin-2-yl}methyl)-N-methyl-N-[2-(2-pyridinyl)ethyl]urea (Preparation 25) in methanol (50 ml). The solution was stirred for 16 hours at room temperature. The solvent was removed under reduced pressure. The residue was dissolved in ethyl acetate (100 ml) and the solution was washed with saturated aqueous sodium hydrogen carbonate solution (50 ml) and then dried over anhydrous magnesium sulphate. The solvent was removed under reduced pressure to give the title compound (0.161 g) as a gum.

Workup

  1. customThe solvent was removed under reduced pressure
  2. dissolutionThe residue was dissolved in ethyl acetate (100 ml)
  3. washthe solution was washed with saturated aqueous sodium hydrogen carbonate solution (50 ml)
  4. dry with materialdried over anhydrous magnesium sulphate
  5. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-d4222af13890455a95e4d655d413e8b2
Source dataset
uspto-grants-2007_07
Patent number
US07238676B2

Reaction notes

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