Acetone → N-Isopropylcyclopentanamine

HRID 1293037Notes

Reaction equation

HRID 1293037 reaction equation
[CH:1]1([NH2:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:7][C:8]([CH3:10])=O>[OH-].[OH-].[Pd+2]>[CH:8]([NH:6][CH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1)([CH3:10])[CH3:7]

Participants

4

Reactant 2

HCID 180AcetoneHCID 2906Cyclopentylamine

Product 1

HCID 17750362N-Isopropylcyclopentanamine

Reagents, catalysts & solvents 1

HCID 9942167Palladium hydroxideCatalyst

Procedure

Pearlman's catalyst (20% w/w palladium hydroxide-on-carbon) (1.5 g) was added to a solution of cyclopentylamine (15 ml, 0.21 mol) in acetone (200 ml). The reaction mixture was stirred under an atmosphere of hydrogen gas at 414 kPa (60 psi). After stirring for 16 hours the reaction mixture was filtered through Arbocel (Trade Mark) and the solvent was removed under reduced pressure to give the title compound (15 ml) as a thin oil.

Workup

  1. stirringAfter stirring for 16 hours the reaction mixture
  2. filtrationwas filtered through Arbocel (Trade Mark)
  3. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-4c7da29820a545e7ae7418d1cbb9ac0b
Source dataset
uspto-grants-2007_07
Patent number
US07238676B2

Reaction notes

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