Methanol → HCID 178425949, compound

HRID 1293132Notes

Reaction equation

HRID 1293132 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[C:3]=1[S:10][C:11]1[N:15]=[CH:14][NH:13][N:12]=1.C[OH:17]>O>[CH3:9][C:4]1[CH:5]=[C:6]([CH3:8])[CH:7]=[C:2]([CH3:1])[C:3]=1[S:10]([C:11]1[N:15]=[CH:14][NH:13][N:12]=1)=[O:17]

Participants

4

Reactant 2

HCID 887MethanolHCID 178425938HCID 178425938, compound

Product 1

HCID 178425949HCID 178425949, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To a mixture of OXONE monopersulfate compound (3.02 g) and water (30 ml) was added dropwise a mixture of 3-(2,4,6-trimethylphenyl)thio-1H-1,2,4-triazole (Example 32-a) (1.08 g) and methanol (30 ml) with stirring it at room temperature. After the addition was completed, the reaction mixture was stirred for 3 hours, and water (20 ml) was added. Precipitated crystals were collected by filtration, and washed with water, ethyl acetate, and hexane in this order to yield the title compound (820 mg).

Workup

  1. additionwas added dropwise
  2. additionAfter the addition
  3. stirringthe reaction mixture was stirred for 3 hours
  4. customPrecipitated crystals
  5. filtrationwere collected by filtration
  6. washwashed with water, ethyl acetate, and hexane in this order

Sources & evidence

ORD record
ord-d6163e94d5b748078d361d5e452d15e8
Source dataset
uspto-grants-2007_07
Patent number
US07238720B2

Reaction notes

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