HCID 13669982, compound → HCID 13669983, compound

HRID 1293136Notes

Reaction equation

HRID 1293136 reaction equation
[N+:1]([C:4]1[C:9]([O:10][CH2:11][C:12]([F:15])([F:14])[F:13])=[CH:8][CH:7]=[CH:6][C:5]=1[CH3:16])([O-])=O>[Pd].C(OCC)(=O)C>[NH2:1][C:4]1[C:9]([O:10][CH2:11][C:12]([F:13])([F:14])[F:15])=[CH:8][CH:7]=[CH:6][C:5]=1[CH3:16]

Participants

4

Reactant 1

HCID 13669982HCID 13669982, compound

Product 1

HCID 13669983HCID 13669983, compoundYield 103.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a mixture of 2-nitro-3-(2,2,2-trifluoroethyl)oxytoluene (4.12 g) and ethyl acetate (30 ml) was added a catalytic amount of 10% palladium/carbon. Then, the mixture was stirred under a hydrogen atmosphere for 4 hours. The catalyst was removed from the reaction solution by filtration, and the filtrate was concentration under reduced pressure to yield the title compound (3.71 g).

Workup

  1. customThe catalyst was removed from the reaction solution by filtration
  2. concentrationconcentration under reduced pressure

Sources & evidence

ORD record
ord-dc8054d1a4a94d8e8b6252444f48eaf2
Source dataset
uspto-grants-2007_07
Patent number
US07238720B2

Reaction notes

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