HCID 57572271, compound → Methyl 4-[({[5-fluoro-2-(4-fluorophenoxy)pyridin-3-yl]carbonyl}amino)methyl]-2-methylbenzoate

HRID 1293174Notes

Reaction equation

HRID 1293174 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:16]([NH:18][CH2:19][C:20]2[CH:29]=[CH:28][C:23]([C:24]([O:26][CH3:27])=[O:25])=[CH:22][CH:21]=2)=[O:17])[C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)=[N:6][CH:7]=1.N[CH2:31]C1C=CC(C(OC)=O)=C(C)C=1>>[F:1][C:2]1[CH:3]=[C:4]([C:16]([NH:18][CH2:19][C:20]2[CH:21]=[CH:22][C:23]([C:24]([O:26][CH3:27])=[O:25])=[C:28]([CH3:31])[CH:29]=2)=[O:17])[C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 57572271HCID 57572271, compoundHCID 57572345Methyl 4-(aminomethyl)-2-methylbenzoate

Product 1

HCID 57572330Methyl 4-[({[5-fluoro-2-(4-fluorophenoxy)pyridin-3-yl]carbonyl}amino)methyl]-2-methylbenzoate

Procedure

The title compound was prepared according to the procedure described in step 3 of Example 1 from 5-fluoro-2-(4-fluorophenoxy)nicotinic acid (step 3 of Example 1) and methyl 4-(aminomethyl)-2-methylbenzoate: 1H-NMR (CDCl3) δ 8.38 (1H, dd, J=8.1, 3.1 Hz), 8.30–8.24 (1H, m), 8.05 (1H, d, J=3.1 Hz), 7.88 (1H, d, J=8.1 Hz), 7.26–7.08 (6H, m), 4.71 (2H, d, J=5.9 Hz), 3.90 (3H, s), 3.87 (3H, s); MS (ESI) m/z 413 (M+H)+, 411 (M−H)−.

Sources & evidence

ORD record
ord-f2fff4219fe342ef91753d687b8ded02
Source dataset
uspto-grants-2007_07
Patent number
US07238714B2

Reaction notes

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