Methyl 4-(aminomethyl)benzoate hydrochloride → Methyl 4-[({[2-(4-fluorophenoxy)-5-(trifluoromethyl)pyridin-3-yl]carbonyl}amino)methyl]benzoate

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 3 of Example 1 from 2-(4-fluorophenoxy)-5-(trifluoromethyl)nicotinic acid (step 3) and methyl 4-(aminomethyl)benzoate hydrochloride: 1H-NMR (CDCl3) δ 8.90 (1H, d, J=2.7 Hz), 8.45 (1H, s), 8.01 (2H, d, J=8.2 Hz), 7.43 (2H, d, J=8.2 Hz), 4.78 (2H, d, J=5.9 Hz), 3.90 (3H, s); MS (ESI) m/z 449 (M+H)+.

Provenance & Evidence