4-Fluorophenol → HCID 57572305, compound

HRID 1293200Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[N:4][C:5](Cl)=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8].[F:13][C:14]1[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]([O:20][C:17]2[CH:18]=[CH:19][C:14]([F:13])=[CH:15][CH:16]=2)=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8]

Participants

Reactant 2

HCID 97324-Fluorophenol

HCID 2763343Methyl 5-bromo-2-chloronicotinate

Product 1

HCID 57572305HCID 57572305, compound

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 56 from methyl 5-bromo-2-chloronicotinate (J. Org. Chem. 1989, 54, 3618–3624) and 4-fluorophenol: 1H-NMR (CDCl3) δ 8.37 (1H, d, J=2.5 Hz), 8.27 (1H, d, J=2.5 Hz), 7.10 (2H, d, J=6.2 Hz), 3.95 (3H, s); MS (ESI) m/z 326 (M+H)+.

Sources & evidence

ORD record: ord-0bce2addbd76456d93d90e8da96075b6
Source dataset: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07238714B2

Reaction notes

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