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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1293207Generated: October 26, 2026

Methyl 2,5-Dichloronicotinate → Methyl 5-chloro-2-(3-fluorobenzyl)nicotinate

https://huagongshe.com/reaction/1293207

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 2,5-DichloronicotinateHCID 2764318—
ReactantHCID 178505699HCID 178505699—
ProductMethyl 5-chloro-2-(3-fluorobenzyl)nicotinateHCID 57572300—

Reaction Steps

The title compound was prepared according to the procedure described in step 2 of Example 58 from methyl 2,5-dichloronicotinate and 3-fluorobenzylzinc chloride: 1H-NMR (CDCl3) δ 8.65 (1H, d, J=2.4 Hz), 8.19 (1H, d, J=2.6 Hz), 7.26–6.84 (4H, m), 4.54 (2H, s), 3.89 (3H, s).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07238714B2
Source datasetuspto-grants-2007_07
ORD IDord-0da2c747914848cfa1650e49cdae876a
Source noteuspto-grants-2007_07