5-Chloro-2-(3-chlorophenoxy)benzoic acid → Methyl 4-((1S)-1-{[5-chloro-2-(3-chlorophenoxy)benzoyl]amino}ethyl)benzoate

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 3 of Example 1 from 5-chloro-2-(3-chlorophenoxy)benzoic acid (step 2) and methyl 4-[(1S)-1-aminoethyl]benzoate hydrochloride (step 3 of Example 5): 1H-NMR (CDCl3) δ 8.17 (1H, d, J=2.8 Hz), 7.93 (2H, m), 7.65 (1H, d, J=7.4 Hz), 7.42–7.19 (5H, m), 6.97–6.81 (3H, m), 5.32 (1H, dq, J=7.4, 6.9 Hz), 3.90 (3H, s), 1.49 (3H, d, J=6.9 Hz).

Provenance & Evidence