Phenol → HCID 69417840, compound

HRID 1293245Notes

Reaction equation

HRID 1293245 reaction equation
Cl[C:2]1[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])=[CH:6][C:5]([Cl:23])=[CH:4][N:3]=1.[C:24]1([OH:30])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[Cl:23][C:5]1[CH:6]=[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])[C:2]([O:30][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 996PhenolHCID 86601543Methyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate

Product 1

HCID 69417840HCID 69417840, compound

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 45 from methyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate (step 1 of Example 48) and phenol: 1H-NMR (CDCl3) δ 8.54 (1H, d, J=2.8 Hz), 8.21 (1H, d, J=7.3 Hz), 8.13 (1H, d, J=2.6 Hz), 8.00 (2H, dd, J=6.6, 1.8 Hz), 7.50–7.41 (4H, m), 7.34–7.29 (1H, m), 7.20–7.15 (2H, m), 5.42–5.33 (1H, m), 3.89 (3H, s), 1.61 (3H, d, J=7.0 Hz); MS (ESI) m/z 411 (M+H)+, 409 (M−H)−.

Sources & evidence

ORD record
ord-c19b95e83ddc48c3ab06bbed4c1b6a54
Source dataset
uspto-grants-2007_07
Patent number
US07238714B2

Reaction notes

Loading…