2,5-Dichlorophenol → HCID 69415791, compound

HRID 1293254Notes

Reaction equation

HRID 1293254 reaction equation
Cl[C:2]1[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])=[CH:6][C:5]([Cl:23])=[CH:4][N:3]=1.[Cl:24][C:25]1[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][C:26]=1[OH:32]>>[Cl:23][C:5]1[CH:6]=[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])[C:2]([O:32][C:26]2[CH:27]=[C:28]([Cl:31])[CH:29]=[CH:30][C:25]=2[Cl:24])=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 662,5-DichlorophenolHCID 86601543Methyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate

Product 1

HCID 69415791HCID 69415791, compound

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 45 from methyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate (step 1 of Example 48) and 2,5-dichlorophenol: 1H-NMR (CDCl3) δ 8.55 (1H, d, J=2.8 Hz), 8.34 (1H, d, J=2.6 Hz), 8.27–7.99 (3H, m), 7.46–7.43 (3H, m), 7.35 (1H, d, J=2.3 Hz), 7.29–7.25 (1H, m), 5.44–5.34 (1H, m), 3.90 (3H, s), 1.61 (3H, d, J=6.9 Hz).

Sources & evidence

ORD record
ord-d87ddd3dc77e43f7883c3f9ef4cd340f
Source dataset
uspto-grants-2007_07
Patent number
US07238714B2

Reaction notes

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