3,4-Dichlorophenol → HCID 69415999, compound

HRID 1293255Notes

Reaction equation

HRID 1293255 reaction equation
Cl[C:2]1[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])=[CH:6][C:5]([Cl:23])=[CH:4][N:3]=1.[Cl:24][C:25]1[CH:26]=[C:27]([OH:32])[CH:28]=[CH:29][C:30]=1[Cl:31]>>[Cl:23][C:5]1[CH:6]=[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])[C:2]([O:32][C:27]2[CH:28]=[CH:29][C:30]([Cl:31])=[C:25]([Cl:24])[CH:26]=2)=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 72583,4-DichlorophenolHCID 86601543Methyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate

Product 1

HCID 69415999HCID 69415999, compound

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 45 from methyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate (step 1 of Example 48) and 3,4-dichlorophenol: 1H-NMR (CDCl3) δ 8.52 (1H, d, J=2.6 Hz), 8.13 (1H, d, J=2.8 Hz), 8.00 (2H, dd, J=6.7, 1.9 Hz), 7.93 (1H, d, J=7.4 Hz), 7.51 (1H, d, J=8.7 Hz), 7.42 (2H, d, J=8.1 Hz), 7.30 (1H, d, J=2.6 Hz), 7.03 (1H, dd, J=8.7, 2.6 Hz), 5.42–5.31 (1H, m), 3.90 (3H, s), 1.60 (3H, d, J=6.9 Hz).

Sources & evidence

ORD record
ord-4e4f5ef95a6f43888f68ea04725fcdcf
Source dataset
uspto-grants-2007_07
Patent number
US07238714B2

Reaction notes

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