3,5-Dichlorophenol → HCID 69415878, compound

HRID 1293256Notes

Reaction equation

HRID 1293256 reaction equation
Cl[C:2]1[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])=[CH:6][C:5]([Cl:23])=[CH:4][N:3]=1.[Cl:24][C:25]1[CH:26]=[C:27]([OH:32])[CH:28]=[C:29]([Cl:31])[CH:30]=1>>[Cl:23][C:5]1[CH:6]=[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])[C:2]([O:32][C:27]2[CH:26]=[C:25]([Cl:24])[CH:30]=[C:29]([Cl:31])[CH:28]=2)=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 115713,5-DichlorophenolHCID 86601543Methyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate

Product 1

HCID 69415878HCID 69415878, compound

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 45 from methyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate (step 1 of Example 48) and 3,5-dichlorophenol: 1H-NMR (CDCl3) δ 8.54 (1H, d, J=2.6 Hz), 8.16 (1H, d, J=2.8 Hz), 8.02 (2H, dd, J=6.6, 1.8 Hz), 7.84 (1H, d, J=7.3 Hz), 7.42 (2H, d, J=8.6 Hz), 7.31 (1H, t, J=1.8 Hz), 7.08 (2H, d, J=1.8 Hz), 5.41–5.31 (1H, m), 3.91 (3H, s), 1.60 (3H, d, J=6.9 Hz).

Sources & evidence

ORD record
ord-ee61d00bb9ee47db995cef648eb45ddd
Source dataset
uspto-grants-2007_07
Patent number
US07238714B2

Reaction notes

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