3,4-Difluorophenol → Methyl 5-chloro-2-(3,4-difluorophenoxy)benzoate

HRID 1293287Notes

Reaction equation

HRID 1293287 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5](F)=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8].[F:13][C:14]1[CH:15]=[C:16]([OH:21])[CH:17]=[CH:18][C:19]=1[F:20]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:21][C:16]2[CH:17]=[CH:18][C:19]([F:20])=[C:14]([F:13])[CH:15]=2)=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8]

Participants

3

Reactant 2

HCID 759273,4-DifluorophenolHCID 21525433Methyl 5-chloro-2-fluorobenzoate

Product 1

HCID 69415844Methyl 5-chloro-2-(3,4-difluorophenoxy)benzoate

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 67 from methyl 5-chloro-2-fluorobenzoate and 3,4-difluorophenol: 1H-NMR (CDCl3) δ 7.92 (1H, d, J=2.8 Hz), 7.46 (1H, dd, J=8.7, 2.8 Hz), 7.11 (1H, q, J=9.1 Hz), 6.95 (1H, d, J=8.7 Hz), 6.85–6.72 (1H, m), 6.71–6.59 (1H, m), 3.83 (3H, s).

Sources & evidence

ORD record
ord-d4a619b8d94540dd95600e9a2be95da1
Source dataset
uspto-grants-2007_07
Patent number
US07238714B2

Reaction notes

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