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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1293287Generated: November 2, 2026

3,4-Difluorophenol → Methyl 5-chloro-2-(3,4-difluorophenoxy)benzoate

https://huagongshe.com/reaction/1293287

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-DifluorophenolHCID 75927—
ReactantMethyl 5-chloro-2-fluorobenzoateHCID 21525433—
ProductMethyl 5-chloro-2-(3,4-difluorophenoxy)benzoateHCID 69415844—

Reaction Steps

The title compound was prepared according to the procedure described in step 1 of Example 67 from methyl 5-chloro-2-fluorobenzoate and 3,4-difluorophenol: 1H-NMR (CDCl3) δ 7.92 (1H, d, J=2.8 Hz), 7.46 (1H, dd, J=8.7, 2.8 Hz), 7.11 (1H, q, J=9.1 Hz), 6.95 (1H, d, J=8.7 Hz), 6.85–6.72 (1H, m), 6.71–6.59 (1H, m), 3.83 (3H, s).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07238714B2
Source datasetuspto-grants-2007_07
ORD IDord-d4a619b8d94540dd95600e9a2be95da1
Source noteuspto-grants-2007_07