2,6-Difluorophenol → HCID 69417845, compound

HRID 1293294Notes

Reaction equation

HRID 1293294 reaction equation
F[C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[F:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[C:17]=1[OH:23]>>[F:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[C:17]=1[O:23][C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]

Participants

3

Reactant 2

HCID 943922,6-DifluorophenolHCID 11217860Methyl 2-Fluoro-5-nitrobenzoate

Product 1

HCID 69417845HCID 69417845, compound

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 67 from methyl 2-fluoro-5-nitrobenzoate (J. Org. Chem. 1990, 55, 2034.) and 2,6-difluorophenol: 1H-NMR (CDCl3) δ 8.83 (1H, d, J=2.8 Hz), 8.25 (1H, dd, J=9.2, 2.8 Hz), 7.32–7.20 (1H, m), 7.12–7.02 (2H, m), 6.82 (1H, d, J=9.2 Hz), 3.98 (3H, s); MS (ESI) m/z 310 (M+H)+.

Sources & evidence

ORD record
ord-a2e622db82bf462790cbdc09507dced6
Source dataset
uspto-grants-2007_07
Patent number
US07238714B2

Reaction notes

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