4-Chloro-2-fluorophenol → HCID 69418246, compound

HRID 1293300Notes

Reaction equation

HRID 1293300 reaction equation
Cl[C:2]1[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:25]=[CH:24][C:16]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])=[CH:6][C:5]([Cl:26])=[CH:4][N:3]=1.[Cl:27][C:28]1[CH:33]=[CH:32][C:31]([OH:34])=[C:30]([F:35])[CH:29]=1>>[Cl:26][C:5]1[CH:6]=[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:25]=[CH:24][C:16]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])[C:2]([O:34][C:31]2[CH:32]=[CH:33][C:28]([Cl:27])=[CH:29][C:30]=2[F:35])=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 1819754-Chloro-2-fluorophenolHCID 57572256tert-butyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate

Product 1

HCID 69418246HCID 69418246, compound

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 45 from tert-butyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate (step 1 of Example 45) and 4-chloro-2-fluorophenol: 1H-NMR (CDCl3) δ 8.53 (1H, d, J=2.7 Hz), 8.10 (1H, d, J=2.7 Hz), 7.97–7.94 (3H, m), 7.42–7.39 (2H, m), 7.31–7.21 (3H, m), 5.37 (1H, quint, J=7.0 Hz), 1.61–1.58 (12H, m); MS (ESI) m/z 505 (M+H)+, 503 (M−H)−.

Sources & evidence

ORD record
ord-bb8227f7e7314191b18f505566bbee4a
Source dataset
uspto-grants-2007_07
Patent number
US07238714B2

Reaction notes

Loading…