4-Fluoro-2-methylphenol → HCID 69418171, compound

HRID 1293310Notes

Reaction equation

HRID 1293310 reaction equation
Cl[C:2]1[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:25]=[CH:24][C:16]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])=[CH:6][C:5]([Cl:26])=[CH:4][N:3]=1.[F:27][C:28]1[CH:33]=[CH:32][C:31]([OH:34])=[C:30]([CH3:35])[CH:29]=1>>[Cl:26][C:5]1[CH:6]=[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:25]=[CH:24][C:16]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])[C:2]([O:34][C:31]2[CH:32]=[CH:33][C:28]([F:27])=[CH:29][C:30]=2[CH3:35])=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 1362954-Fluoro-2-methylphenolHCID 57572256tert-butyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate

Product 1

HCID 69418171HCID 69418171, compound

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 45 from tert-butyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate (step 1 of Example 45) and 4-fluoro-2-methylphenol: 1H-NMR (CDCl3) δ 8.57 (1H, d, J=2.6 Hz), 8.22 (1H, d, J=7.6 Hz), 8.11 (1H, d, J=2.6 Hz), 7.96 (2H, d, J=8.4 Hz), 7.41 (2H, d, J=8.4 Hz), 7.13–6.93 (3H, m), 5.39 (1H, dq, J=7.6, 6.9 Hz), 2.12 (3H, s), 1.60 (3H, d, J=6.9 Hz), 1.58 (9H, s); MS (ESI) m/z 485 (M+H)+, 483 (M−H)−.

Sources & evidence

ORD record
ord-7e603b42406349dba0a2e609f663f215
Source dataset
uspto-grants-2007_07
Patent number
US07238714B2

Reaction notes

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