2-Chloro-4-fluorophenol → HCID 69416999, compound

HRID 1293318Notes

Reaction equation

HRID 1293318 reaction equation
Cl[C:2]1[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])=[CH:6][C:5]([F:23])=[CH:4][N:3]=1.[Cl:24][C:25]1[CH:30]=[C:29]([F:31])[CH:28]=[CH:27][C:26]=1[OH:32]>>[Cl:24][C:25]1[CH:30]=[C:29]([F:31])[CH:28]=[CH:27][C:26]=1[O:32][C:2]1[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])=[CH:6][C:5]([F:23])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 748142-Chloro-4-fluorophenolHCID 86760502HCID 86760502, compound

Product 1

HCID 69416999HCID 69416999, compound

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 45 from methyl 4-((1S)-1-{[(2-chloro-5-fluoropyridin-3-yl)carbonyl]amino}ethyl)benzoate (step 1) and 2-chloro-4-fluorophenol: 1H-NMR (CDCl3) δ 8.32 (1H, dd, J=8.1, 2.9 Hz), 8.19 (1H, d, J=7.3 Hz), 8.02–7.99 (3H, m), 7.45 (2H, d, J=8.3 Hz), 7.32–7.25 (2H, m), 7.14–7.08 (1H, m), 5.39 (1H, m), 3.90 (3H, s), 1.61 (3H, d, J=7.0 Hz).

Sources & evidence

ORD record
ord-4e42f12fe56c43428f18a8d23830d730
Source dataset
uspto-grants-2007_07
Patent number
US07238714B2

Reaction notes

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