(S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride → Methyl 4-((1S)-1-{[5-cyano-2-(3-fluorophenoxy)benzoyl]amino}ethyl)benzoate

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 3 of Example 1 from 5-cyano-2-(3-fluorophenoxy)benzoic acid (step 1) and methyl 4-[(1S)-1-aminoethyl]benzoate hydrochloride (step 3 of Example 5): 1H-NMR (CDCl3) δ 8.54 (1H, s), 7.97 (2H, d, J=8.4 Hz), 7.77–7.65 (2H, m), 7.47–7.34 (3H, m), 7.04–6.80 (4H, m), 5.35 (1H, m), 3.90 (3H, s), 1.54 (3H, d, J=7.8 Hz).

Provenance & Evidence