2-Amino-2-methyl-1-propanol → HCID 64538625, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-amino-2-methyl-1-propanol (0.5 mL, 5.60 mmol), in DMF (20 mL) was added NaH 60% (0.67 g, 16.80 mmol) and then 6-chloronicotinonitrile (2.03 g, 11.22 mmol). The mixture heated to 70° C. for 2 hours and then stirred at room temperature overnight. The reaction mixture was taken up in H2O and extracted with EtOAc. The organic phase was washed with water (3×), dried over Na2SO4 and concentrated under reduced pressure to provide the titled compound as a pale yellow solid. MS (DCI) m/z 235 (M+H)+.

Provenance & Evidence