反应详情

温度

70 °C

To a solution of 2-amino-2-methyl-1-propanol (0.5 mL, 5.60 mmol), in DMF (20 mL) was added NaH 60% (0.67 g, 16.80 mmol) and then 6-chloronicotinonitrile (2.03 g, 11.22 mmol). The mixture heated to 70° C. for 2 hours and then stirred at room temperature overnight. The reaction mixture was taken up in H2O and extracted with EtOAc. The organic phase was washed with water (3×), dried over Na2SO4 and concentrated under reduced pressure to provide the titled compound as a pale yellow solid. MS (DCI) m/z 235 (M+H)+.

1. extractionextracted with EtOAc
2. washThe organic phase was washed with water (3×)
3. dry with materialdried over Na2SO4
4. concentrationconcentrated under reduced pressure