反应详情

Intermediate 18 was heated in HBr (30-33%) in glacial acetic acid (25 ml) at 50° C. for 7-8 h The reaction contents were poured in ice-water and extracted with ethyl acetate. The organic layer was washed with saturated sodium bicarbonate, and extracted with 10% sodium hydroxide (3×25 ml) solution. The aqueous layer was acidified with conc. HCl to give a white precipitate which was filtered and air dried to obtain the crude product as a white solid (3.2 gm).

1. customThe reaction contents
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed with saturated sodium bicarbonate
4. extractionextracted with 10% sodium hydroxide (3×25 ml) solution
5. customto give a white precipitate which
6. filtrationwas filtered
7. customair dried