反应详情

Intermediate 38 (550 mg, 2.26 mmol) was taken in methanol (10 ml) and raney nickel catalyst (100 mg, 18% w/w) was added. The reaction mixture was refluxed and to this was added hydrazine hydrate (99%) solution (2 ml) slowly over a period of 10 min. The refluxing continued for 2 h. The catalyst was filtered and the filterate was concentrated and diluted with water (100 ml) and further extracted with ethyl acetate (3×25 ml). The organic layer was washed with water and concentrated to give the product as brown solid (500 mg);mp: 167-169° C.

1. temperatureThe reaction mixture was refluxed
2. filtrationThe catalyst was filtered
3. concentrationthe filterate was concentrated
4. additiondiluted with water (100 ml)
5. extractionfurther extracted with ethyl acetate (3×25 ml)
6. washThe organic layer was washed with water
7. concentrationconcentrated