Sodium Hydroxide → HCID 69282843, compound

HRID 1293482Notes

Reaction equation

HRID 1293482 reaction equation
C[O:2][C:3]([C:5]1[C:17]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]([CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:9]=2[C:8]([O:25][CH2:26][CH3:27])=[CH:7][CH:6]=1)=[O:4].[OH-].[Na+]>CO>[CH2:18]([N:10]1[C:9]2[C:8]([O:25][CH2:26][CH3:27])=[CH:7][CH:6]=[C:5]([C:3]([OH:4])=[O:2])[C:17]=2[C:16]2[C:11]1=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69280150HCID 69280150, compound

Product 1

HCID 69282843HCID 69282843, compoundYield 85.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of methyl-9-benzyl-1-ethoxy-9H-4-carbazolecarboxylate (728 mg, 2.027 mmoles), in methanol (10 ml), aqueous sodium hydroxide (81 mg, 2.027 mmoles) was added and the reaction mixture was refluxed for 1 hr. Methanol was evaporated under reduced pressure, the reaction mixture was acidified with 1N HCl and filtered to yield 599 mg of title compound as an off-white solid.

Workup

  1. temperaturethe reaction mixture was refluxed for 1 hr
  2. customMethanol was evaporated under reduced pressure
  3. filtrationfiltered

Sources & evidence

ORD record
ord-69d8a4714d2341749ce12a82aa4c5639
Source dataset
uspto-grants-2007_07
Patent number
US07238725B2

Reaction notes

Loading…