Hydrochloric Acid → HCID 23187837, compound

HRID 129352Notes

Reaction equation

HRID 129352 reaction equation
[CH:1]1[C:6]([OH:7])=[CH:5][C:4]2[O:8]C([S:11][C:3]=2[CH:2]=1)=O.[OH-].[Na+].[CH:14](I)([CH3:16])[CH3:15].Cl>>[CH:14]([S:11][C:3]1[CH:2]=[CH:1][C:6]([OH:7])=[CH:5][C:4]=1[OH:8])([CH3:16])[CH3:15]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 6362Isopropyl iodideHCID 14798Sodium HydroxideHCID 721396-Hydroxy-1,3-benzoxathiol-2-one

Product 1

HCID 23187837HCID 23187837, compound

Procedure

8.4 g of tioxolone (1 eq) are added to an aqueous sodium hydroxide solution (3.5 eq) (6.7 g of sodium hydroxide in 84 ml of water) at room temperature. After complete dissolution (30 minutes), 5.5 ml of isopropyl iodide are added. After stirring for two hours at room temperature, the mixture is acidified with hydrochloric acid and then extracted with ethyl ether. The organic phases are washed, dried and evaporated. The residue is recrystallized from an alcohol/water mixture to obtain pale-yellow crystals having a melting point of: 67° C.

Workup

  1. additionare added
  2. extractionextracted with ethyl ether
  3. washThe organic phases are washed
  4. customdried
  5. customevaporated
  6. customThe residue is recrystallized from an alcohol/water mixture
  7. customto obtain pale-yellow crystals

Sources & evidence

ORD record
ord-59911fa1fb0348ceb7fc001ca2985ce9
Source dataset
uspto-grants-1995_11
Patent number
US05468472

Reaction notes

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