Hydrochloric Acid → 3-Ethoxy-4-nitrobenzoic acid

HRID 1293542Notes

Reaction equation

HRID 1293542 reaction equation
[OH-].[K+].F[C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[N+:13]([O-:15])=[O:14])[C:7]([OH:9])=[O:8].Cl.[CH2:17]([OH:19])[CH3:18]>>[CH2:17]([O:19][C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[N+:13]([O-:15])=[O:14])[C:7]([OH:9])=[O:8])[CH3:18]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 2306533-Fluoro-4-nitrobenzoic acid

Product 1

HCID 223975093-Ethoxy-4-nitrobenzoic acid

Procedure

Potassium hydroxide (0.278 g) was added to a solution of 3-fluoro-4-nitrobenzoic acid (0.4 g) in ethanol (7 ml) and the reaction treated with microwaves (300 W, 100° C.) for 5 minutes. The reaction mixture was acidified using 2N HCl and extracted with ethyl acetate. The extracts were combined, washed with water, dried (MgSO4) and evaporated to give 3-ethoxy-4-nitro-benzoic acid (0.325 g).

Workup

  1. additionthe reaction treated with microwaves (300 W, 100° C.) for 5 minutes
  2. extractionextracted with ethyl acetate
  3. washwashed with water
  4. dry with materialdried (MgSO4)
  5. customevaporated

Sources & evidence

ORD record
ord-02e916be03db41cd803523321332b904
Source dataset
uspto-grants-2007_07
Patent number
US07238811B2

Reaction notes

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