Tert-Butylamine → 5-Bromo-N-tert-butylpyridine-3-sulfonamide

HRID 1293601Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([S:8](Cl)(=[O:10])=[O:9])[CH:5]=[N:6][CH:7]=1.[C:12]([NH2:16])([CH3:15])([CH3:14])[CH3:13]>>[C:12]([NH:16][S:8]([C:4]1[CH:5]=[N:6][CH:7]=[C:2]([Br:1])[CH:3]=1)(=[O:10])=[O:9])([CH3:15])([CH3:14])[CH3:13]

Participants

Reactant 2

HCID 6385Tert-Butylamine

HCID 203244745-Bromopyridine-3-sulfonyl chloride

Product 1

HCID 617949515-Bromo-N-tert-butylpyridine-3-sulfonamideYield 108%

Procedure

Prepared by general procedure III from 5-bromo-pyridine-3-sulfonyl chloride (Example B.2 step 2) (500 mg, 2 mmol) and tert-butylamine (1.03 mL, 10 mmol) to give the title compound as a white solid (620 mg, 108%). MS (ISP) 293.0 [(M+H)+], 295.2 [(M+2+H)+]. mp 110° C.

Sources & evidence

ORD record: ord-5d392f7e978e4a7692f3ef5812fe9e38
Source dataset: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07238808B2

Reaction notes

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