2-Amino-2-methyl-1-propanol → 5-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-2-methoxybenzenesulfonamide

HRID 1293605Notes

Reaction equation

HRID 1293605 reaction equation
[NH2:1][C:2]([CH3:6])([CH3:5])[CH2:3][OH:4].[Br:7][C:8]1[CH:9]=[CH:10][C:11]([O:18][CH3:19])=[C:12]([S:14](Cl)(=[O:16])=[O:15])[CH:13]=1>>[Br:7][C:8]1[CH:9]=[CH:10][C:11]([O:18][CH3:19])=[C:12]([S:14]([NH:1][C:2]([CH3:6])([CH3:5])[CH2:3][OH:4])(=[O:15])=[O:16])[CH:13]=1

Participants

3

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 5200205-Bromo-2-methoxybenzene-1-sulfonyl chloride

Product 1

HCID 275180375-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-2-methoxybenzenesulfonamideYield 99.3%

Procedure

Prepared by general procedure III from 2-amino-2-methyl-1-propanol (2.23 g, 25 mmol) and commercially available 5-bromo-2methoxybenzenesulfonyl chloride (1.43 g, 5 mmol) to give the title compound as an off-white solid (1.68 g, 99%). MS (ISN) 336.2 [(M−H)−], 338.1 [(M+2−H)−]. mp 168° C.

Sources & evidence

ORD record
ord-13e98cd1a8b144b3b84c99d469fb0681
Source dataset
uspto-grants-2007_07
Patent number
US07238808B2

Reaction notes

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