Phosphorus oxychloride → HCID 15278638, compound

HRID 129386Notes

Reaction equation

HRID 129386 reaction equation
P(Cl)(Cl)(Cl)(Cl)Cl.[F:7][C:8]1[C:21]([NH:22][C:23](=O)[CH3:24])=[CH:20][C:11]2[N:12]([CH2:17][C:18]#[CH:19])[C:13](=[O:16])[CH2:14][O:15][C:10]=2[CH:9]=1.P(Cl)(Cl)([Cl:28])=O>C1C=CC=CC=1>[F:7][C:8]1[C:21]([N:22]=[C:23]([Cl:28])[CH3:24])=[CH:20][C:11]2[N:12]([CH2:17][C:18]#[CH:19])[C:13](=[O:16])[CH2:14][O:15][C:10]=2[CH:9]=1

Participants

5

Reactant 3

HCID 24813Phosphorus oxychlorideHCID 24819Phosphorus pentachlorideHCID 15278637HCID 15278637, compound

Product 1

HCID 15278638HCID 15278638, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

First, 10 ml of benzene and 0.4 g of phosphorus pentachloride were added to 0.5 g of N-(7-fluoro-4-propargyl-2H-1,4-benzoxazine-3(4H)-one-6-yl)-acetamide, and the stirring was continued for 1.0 hr at 60° C. After letting the mixture stand to cool the same, the produced phosphorus oxychloride and benzene were distilled out under reduced pressure to quantitatively obtain N-(7-fluoro-4-propargyl-2H-1,4-benzoxazine-3(4H)-one-6-yl)-acetimidoylchloride.

Workup

  1. distillationwere distilled out under reduced pressure to quantitatively obtain N-(7-fluoro-4-propargyl-2H-1,4-benzoxazine-3(4H)-one-6-yl)-acetimidoylchloride

Sources & evidence

ORD record
ord-45cf9045523d41d8acaa3a01109272ca
Source dataset
uspto-grants-1995_11
Patent number
US05468719

Reaction notes

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