Hydrochloric Acid → HCID 15278472, compound

Participants

Reaction Steps

3.8 g of ethoxymethyl 6-chloro-2-[(4,6-dimethoxy-2-pyrimidyl)methyloxy]benzoate was stirred in a mixed solvent of 30 ml of methanol and 10 ml of water, 0.5 ml of concentrated hydrochloric acid was added, and the mixture was subjected to reaction at room temperature for about 2 hours. The reaction solution was diluted with water and extracted with chloroform, the extract was dried over anhydrous sodium sulfate, and the solvent was distilled off to obtain 3.1 g of 6-chloro-2-[(4,6-dimethoxy-2-pyrimidyl)methyloxy]benzoic acid (yield 95%).

Provenance & Evidence