Hydrochloric Acid → HCID 15278472, compound

HRID 129391Notes

Reaction equation

HRID 129391 reaction equation
[Cl:1][C:2]1[C:7]([C:8]([O:10]COCC)=[O:9])=[C:6]([O:15][CH2:16][C:17]2[N:22]=[C:21]([O:23][CH3:24])[CH:20]=[C:19]([O:25][CH3:26])[N:18]=2)[CH:5]=[CH:4][CH:3]=1.CO.Cl>O>[Cl:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[C:6]([O:15][CH2:16][C:17]2[N:18]=[C:19]([O:25][CH3:26])[CH:20]=[C:21]([O:23][CH3:24])[N:22]=2)[CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 15786506HCID 15786506, compound

Product 1

HCID 15278472HCID 15278472, compoundYield 96.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

3.8 g of ethoxymethyl 6-chloro-2-[(4,6-dimethoxy-2-pyrimidyl)methyloxy]benzoate was stirred in a mixed solvent of 30 ml of methanol and 10 ml of water, 0.5 ml of concentrated hydrochloric acid was added, and the mixture was subjected to reaction at room temperature for about 2 hours. The reaction solution was diluted with water and extracted with chloroform, the extract was dried over anhydrous sodium sulfate, and the solvent was distilled off to obtain 3.1 g of 6-chloro-2-[(4,6-dimethoxy-2-pyrimidyl)methyloxy]benzoic acid (yield 95%).

Workup

  1. additionwas added
  2. customthe mixture was subjected to reaction at room temperature for about 2 hours
  3. extractionextracted with chloroform
  4. dry with materialthe extract was dried over anhydrous sodium sulfate
  5. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-8e984e3672dc46c1917a06781e48208b
Source dataset
uspto-grants-1995_11
Patent number
US05468721

Reaction notes

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