Sodium Hydroxide → 2(S)-(Piperidin-2-on-1-yl)-3-methylbutanoic acid

HRID 129398Notes

Reaction equation

HRID 129398 reaction equation
[N:1]1([C@@H:8]([CH:13]([CH3:15])[CH3:14])[C:9]([O:11]C)=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][C:2]1=[O:7].[OH-].[Na+]>CO>[N:1]1([C@@H:8]([CH:13]([CH3:15])[CH3:14])[C:9]([OH:11])=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][C:2]1=[O:7]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 15283804Methyl 2(S)-(piperidin-2-on-1-yl)-3-methylbutanoate

Product 1

HCID 152838052(S)-(Piperidin-2-on-1-yl)-3-methylbutanoic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The product of Step B was dissolved in 4 mL of methanol and 0.85 mL of 1N NaOH was added. The mixture was stirred overnight and the solvent was evaporated. The residue was dissolved in water, filtered and acidified. Ethyl acetate extraction and standard workup gave 30 mg of the title compound.

Workup

  1. customthe solvent was evaporated
  2. dissolutionThe residue was dissolved in water
  3. filtrationfiltered
  4. extractionEthyl acetate extraction and standard workup

Sources & evidence

ORD record
ord-20674ea2b1934c38acbceef520a6098b
Source dataset
uspto-grants-1995_11
Patent number
US05468733

Reaction notes

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