反应详情

A mixture of methyl 3-amino-3-methyl-butyrate hydrochloride (10.5 g; 62.6 mmoles) and methyl amine (33% solution in ethanol; 55 ml) is refluxed for 18 hours. The solvent is evaporated, the crude is dissolved in methylene chloride (100 ml) and washed with a saturate aqueous solution of sodium chloride (10 ml). After drying over sodium sulphate and evaporation of the solvent to dryness, N-methyl-3-amino-3-methyl-butyramide is obtained; chromatographically pure colorless oil (T.L.C., eluent--methylene chloride:methanol:NH4OH=80:15:1)

1. temperatureis refluxed for 18 hours
2. customThe solvent is evaporated
3. dissolutionthe crude is dissolved in methylene chloride (100 ml)
4. washwashed with a saturate aqueous solution of sodium chloride (10 ml)
5. dry with materialAfter drying over sodium sulphate and evaporation of the solvent to dryness