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HRID1294077

反应详情

EQUATION

反应方程式

HRID 1294077 反应方程式

REACTANTS

反应物

3
N-Acetylaminobenzene 分子结构式
HCID904

N-Acetylaminobenzene

C8H9NO

HCID 6451240 分子结构式
HCID6451240

未命名化合物

3,4-dinitrobenzoyl Chloride 分子结构式
HCID11806491

3,4-dinitrobenzoyl Chloride

C7H3ClN2O5

PRODUCTS

产物

1
N-[4-(3,4-Dinitrobenzoyl)phenyl]acetamide 分子结构式
HCID17755534

N-[4-(3,4-Dinitrobenzoyl)phenyl]acetamide

C15H11N3O6

收率 6.6%

AUXILIARIES

试剂、催化剂与溶剂

1
Dichloromethane 分子结构式
溶剂HCID6344

Dichloromethane

CH2Cl2

CONDITIONS

反应条件

温度
40 °C

PROCEDURE

实验过程

A mixture of 3,4-dinitrobenzoyl chloride (4 mmol), acetoanilide (540 mg, 4 mmol), and AlCl3 (1.6 g) in CH2Cl2 was heated at 40° C. for 24 h. The slurry was washed with HCl (aq) and the product was extracted with ether. It was washed with K2CO3 (aq), dried, and evaporated. Purification by column-chromatography on silica-gel (hexane:AcOEt=1:3) provided 87 mg of the title compound; MS m/e 328 (M−1).

WORKUP

后处理

  1. washThe slurry was washed with HCl (aq)
  2. extractionthe product was extracted with ether
  3. washIt was washed with K2CO3 (aq)
  4. customdried
  5. customevaporated
  6. customPurification by column-chromatography on silica-gel (hexane:AcOEt=1:3)