HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1294077Generated: October 29, 2026
Acetanilide → N-[4-(3,4-Dinitrobenzoyl)phenyl]acetamide
https://huagongshe.com/reaction/1294077
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetanilide | HCID 904 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 3,4-dinitrobenzoyl Chloride | HCID 11806491 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[4-(3,4-Dinitrobenzoyl)phenyl]acetamide | HCID 17755534 | 6.6% |
Reaction Steps
A mixture of 3,4-dinitrobenzoyl chloride (4 mmol), acetoanilide (540 mg, 4 mmol), and AlCl3 (1.6 g) in CH2Cl2 was heated at 40° C. for 24 h. The slurry was washed with HCl (aq) and the product was extracted with ether. It was washed with K2CO3 (aq), dried, and evaporated. Purification by column-chromatography on silica-gel (hexane:AcOEt=1:3) provided 87 mg of the title compound; MS m/e 328 (M−1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07238813B2 |
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| Source dataset | uspto-grants-2007_07 |
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| ORD ID | ord-4349b20b0a53459590cf7676c88ddd05 |
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| Source note | uspto-grants-2007_07 |
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