反应详情

To a solution of 50 mg of 4-(4-iodo-1-oxobutyl)-α,α-dimethylphenylacetic acid, prepared in accordance with Example 3, in 3 mL of methanol was added 50 mg of NaBH4. The mixture was stirred for 30 minutes, acidified with 2N HCl, and the methanol-removed in vacuo. The concentrate was extracted with EtOAc. The organics were dried over Na2SO4, filtered, and concentrated to afford 40 mg of 4-(1-hydroxy-4-iodobutyl)-α,α-dimethylphenylacetic add.

1. customthe methanol-removed in vacuo
2. extractionThe concentrate was extracted with EtOAc
3. dry with materialThe organics were dried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated
6. customto afford 40 mg of 4-(1-hydroxy-4-iodobutyl)-α,α-dimethylphenylacetic
7. additionadd