反应详情

A mixture of 2-(2-benzyloxy-5-methoxymethoxyphenyl)acetonitrile (2.95 g), 5% palladium carbon (2.0 g) and tetrahydrofuran (100 mL) was subjected to catalytic hydrogenation at room temperature and 4.8 atm. After filtering off the catalyst, the solvent was evaporated under reduced pressure to give crystals (1.88 g, 94%) of 2-(2-hydroxy-5-methoxymethoxyphenyl)acetonitrile. Recrystallization from ethyl acetate-hexane gave pale-brown prism crystals. melting point: 68-69° C.

1. customwas subjected to catalytic hydrogenation at room temperature
2. filtrationAfter filtering off the catalyst
3. customthe solvent was evaporated under reduced pressure