反应详情

A mixture of 2-[5-methoxymethoxy-2-[4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]phenyl]acetonitrile (1.83 g), 10% sulfuric acid (5 mL) and tetrahydrofuran (50 mL) was heated under reflux for 3 hrs. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed successively with saturated aqueous sodium hydrogencarbonate and saturated brine, dried over anhydrous magnesium sulfate, and concentrated to give crystals (1.13 g, 68%) of 2-[5-hydroxy-2-[4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]phenyl]acetonitrile. Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 185-186° C.

1. temperaturewas heated
2. temperatureunder reflux for 3 hrs
3. extractionthe mixture was extracted with ethyl acetate
4. washThe organic layer was washed successively with saturated aqueous sodium hydrogencarbonate and saturated brine
5. dry with materialdried over anhydrous magnesium sulfate
6. concentrationconcentrated