Toluene → 2-[4-[(5-Methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]-3-pyridinecarbaldehyde

HRID 1294133Notes

Reaction equation

HRID 1294133 reaction equation
[C:1]([C:3]1[C:4]([O:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]3[N:20]=[C:21]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[O:22][C:23]=3[CH3:24])=[CH:13][CH:12]=2)=[N:5][CH:6]=[CH:7][CH:8]=1)#N.C1(C)C=CC=CC=1.[H-].C([Al+]CC(C)C)C(C)C.[Cl-].[NH4+].C(OCC)(=[O:52])C>CCCCCC>[CH3:24][C:23]1[O:22][C:21]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[N:20][C:19]=1[CH2:18][O:17][C:14]1[CH:15]=[CH:16][C:11]([CH2:10][O:9][C:4]2[C:3]([CH:1]=[O:52])=[CH:8][CH:7]=[CH:6][N:5]=2)=[CH:12][CH:13]=1

Participants

7

Reactant 5

HCID 1140TolueneHCID 8857Ethyl AcetateHCID 25517Ammonium ChlorideHCID 21225700DiisobutylaluminumhydrideHCID 688862202-({4-[(5-Methyl-2-phenyl-4-oxazolyl)methoxy]benzyl}oxy)nicotinonitrile

Product 1

HCID 865915752-[4-[(5-Methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]-3-pyridinecarbaldehydeYield 76%

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

To a mixture of 3-cyano-2-[4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]pyridine (8.42 g) and anhydrous toluene (300 mL) was dropwise added a solution (1M, 46.6 mL) of diisobutylaluminum hydride in hexane at −78° C. The reaction mixture was allowed to warm to room temperature over 1 hr with stirring. A saturated aqueous ammonium chloride solution (70 L) was dropwise added to the mixture, and the mixture was further stirred at room temperature for 30 min. Ethyl acetate (300 mL) was added to the mixture and, after stirring the mixture at room temperature for 30 min., insoluble materials were filtered off. The filtrate, was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated. The obtained residue was subjected to silica gel column chromatography to give crystals (6.49 g, 76%) of 2-[4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]-3-pyridinecarbaldehyde from a fraction eluted with ethyl acetate-hexane (1:4, v/v). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 97-98° C.

Workup

  1. stirringthe mixture was further stirred at room temperature for 30 min
  2. stirringafter stirring the mixture at room temperature for 30 min.
  3. filtrationinsoluble materials were filtered off
  4. washThe filtrate, was washed with saturated brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-8abacef81581491b9cec5c2a59fd8f16
Source dataset
uspto-grants-2007_07
Patent number
US07238716B2

Reaction notes

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