反应详情

To a mixture of 2-[4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]-3-pyridinecarbaldehyde (0.40 g), ethanol (10 mL) and tetrahydrofuran (10 mL) was added sodium borohydride (0.04 g) at 0° C., and the mixture was stirred at room temperature for 1 hr. Water was added to the reaction mixture, and the precipitated solid was collected by filtration, and dried with air to give crystals (0.35 g, 88%) of [2-[4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]-3-pyridyl]methanol. Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 139-140° C.

1. filtrationthe precipitated solid was collected by filtration
2. customdried with air