HCID 25128463, compound → HCID 17861339, compound

HRID 1294148Notes

Reaction equation

HRID 1294148 reaction equation
C([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][O:17][CH3:18])[CH:12]=[CH:11][C:10]=1/[CH:19]=[CH:20]/[C:21]([O:23][CH2:24][CH3:25])=[O:22])C1C=CC=CC=1>[C].[Pd].C(O)C>[OH:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][O:17][CH3:18])[CH:12]=[CH:11][C:10]=1[CH2:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]

Participants

4

Reactant 1

HCID 25128463HCID 25128463, compound

Product 1

HCID 17861339HCID 17861339, compoundYield 84%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

A mixture of ethyl (E)-3-(2-benzyloxy-4-methoxymethoxyphenyl)-2-propenoate (14.80 g), 5% palladium carbon (20.0 g) and ethanol (300 mL) was subjected to catalytic hydrogenation at room temperature and 1 atm. After filtering off the catalyst, the solvent was evaporated under reduced pressure to give ethyl 3-(2-hydroxy-4-methoxymethoxyphenyl)propionate as a colorless oil (9.17 g, 84%).

Workup

  1. customwas subjected to catalytic hydrogenation at room temperature
  2. filtrationAfter filtering off the catalyst
  3. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-93907ef5e8f54ae0b349d67533477dc3
Source dataset
uspto-grants-2007_07
Patent number
US07238716B2

Reaction notes

Loading…