反应详情

To a mixture of methyl-5-[3-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]nicotinate (0.50 g) and tetrahydrofuran (10 mL) was added lithium aluminum hydride (0.045 g) under ice-cooling, and the mixture was stirred at room temperature for 3 hrs. Sodium sulfate 1.0 hydrate (0.39 g) was added to the mixture and the mixture was further stirred at room temperature for 30 min. The insoluble materials were removed by filtration, and the filtrate was concentrated to give crystals (0.47 g, 98%) of [5-[3-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyloxy]-3-pyridyl]methanol. Recrystallization from ethyl acetate-hexane gave colorless needle crystals. melting point: 145-146° C.

1. temperaturecooling
2. stirringthe mixture was further stirred at room temperature for 30 min
3. customThe insoluble materials were removed by filtration
4. concentrationthe filtrate was concentrated