反应详情

温度

25 °C

(4-[(5-Methyl-2-phenyl-4-oxazolyl)methoxy]phenyl)methanol (400 g) and then 2-chloro-3-cyanopyridine (206.7 g) were added to dimethylformamide (1.6 L). To the obtained mixture was added triturated sodium hydroxide (59.4 g) and the mixture was stirred at 20-30° C. for 48 hrs. Water (1.6 L) was dropwise added at the same temperature and the mixture was stirred for 2 hrs. The precipitated crystals were collected by filtration, washed with water (1.6 L) and then ice-cooled ethyl acetate (800 ml), and dried (40° C.) under reduced pressure to give 2-({4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyl}oxy)nicotinonitrile as white crystals.

1. additionTo the obtained mixture was added
2. customtriturated sodium hydroxide (59.4 g)
3. additionWater (1.6 L) was dropwise added at the same temperature
4. stirringthe mixture was stirred for 2 hrs
5. filtrationThe precipitated crystals were collected by filtration
6. washwashed with water (1.6 L)
7. temperatureice-cooled ethyl acetate (800 ml)
8. customdried (40° C.) under reduced pressure