HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1294362Generated: November 3, 2026
Hydrochloric Acid → 2-(trans)-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropanecarboxylic Acid
https://huagongshe.com/reaction/1294362
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (trans)-2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarboxylic acid ethyl ester | HCID 66578250 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 2-(trans)-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropanecarboxylic Acid | HCID 67494736 | — |
Reaction Steps
A mixture of ester from step 2 and NaOH (20%, 30 mL) was heated to 100° C. for 1.5 h, cooled to rt, acidified with HCl 10% and extracted with EtOAc. The organic extract was dried over Na2SO4 and the solvent evaporated to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07238706B2 |
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| Source dataset | uspto-grants-2007_07 |
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| ORD ID | ord-d15eab87939f488b96d245097202188f |
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| Source note | uspto-grants-2007_07 |
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